Clonorchis sinensis infection contributes to hepatocellular carcinoma progression via enhancing angiogenesis.

ABSTRACT:

Background

Clonorchis sinensis (C. sinensis) infection plays an important role in the progression of hepatocarcinogenesis. However, its specific role in HCC progression remains unclear. This study aimed to investigate whether C. sinensis contributes to angiogenesis in HCC.

Methods

A comprehensive clinical analysis was conducted on 947 HCC patients, divided into two groups: C. sinensis (-) HCC and C. sinensis (+) HCC. Kaplan-Meier survival curves and log-rank tests were utilized to assess survival outcomes. Microvessel density (MVD) was evaluated through CD34 immunohistochemistry on hepatectomy specimens. A chemistry analyzer and blood analyzer were employed to measure the concentration of circulating angiogenesis-related biomarkers. Quantitative reverse transcription-PCR (qR

SUBMITTER: Wei C 

PROVIDER: S-EPMC11554034 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature