RTA408 alleviates retinal ganglion cells damage in mouse glaucoma by inhibiting excessive autophagy.

ABSTRACT:

Background

Glaucoma, characterized by a high incidence and significant ocular harm, has been elucidated through various mechanisms. Excessive autophagy leading to the loss of retinal ganglion cells (RGCs) is suggested as one potential cause for visual impairment in glaucoma.

Methods

A glaucoma model was established through anterior chamber injection of silicone oil in mice. RTA408 and the positive control tafluprost were administered for intervention. The efficacy was preliminarily assessed by intraocular pressure measurement. HE staining and fluorescent staining were used to assess RGC loss, while fluorescent staining and western blot were employed to evaluate the expression of Nrf2. The role of autophagy in the pathogenesis of glaucoma was investigated by artificially modu

SUBMITTER: Qian H 

PROVIDER: S-EPMC11554135 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature