Gastroesophageal reflux disease and risk of incident lung cancer: A large prospective cohort study in UK Biobank.

ABSTRACT:

Background

Some pathogenic mechanisms suggest a potential relationship between gastroesophageal reflux disease (GERD) and respiratory diseases. However, evidence regarding the association between GERD and lung cancer is mixed. We aim to explore this relationship based on data from the large-scale UK Biobank study.

Materials and methods

We performed a cross-sectional and prospective cohort study in 501,569 (45.58% male) individuals included in the UK Biobank at baseline (2006-2010). The Cox proportional hazards model and logistic regression models were used to assess the relationship between GERD and lung cancer, small cell lung cancer (SCLC), lung squamous cell carcinoma (LUSC), and lung adenocarcinoma (LUAD).

Results

During a mean follow-up of 11.54 years, 3,863 (0.8

SUBMITTER: Liao Y 

PROVIDER: S-EPMC11554179 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature