Anti-inflammatory effects of <i>para</i>-quinone methide derivatives on ulcerative colitis.

ABSTRACT: A series of para-quinone methide derivatives were evaluated their anti-inflammatory activity. Through the screening of the lipopolysaccharide (LPS)-induced inflammatory cell model in Raw264.7 cells, it was found that the inhibitory activity of meta-substituted derivatives on NO production was superior to that of ortho- and para-substituted derivatives. Among them, in the inflammatory cell model, the meta-trifluoromethyl substituted para-quinone methide derivative 1i had the best activity in inhibiting LPS-induced excess generation of NO. And 1i could effectively inhibit the increase of ROS in inflammatory cells, the expression of iNOS related to the production of NO, and the expressions of inflammation related initiating protein TLR4,

SUBMITTER: Qiu Y 

PROVIDER: S-EPMC11554457 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature