SOX17 expression in tumor-penetrating vessels in relation to CD8⁺ T-cell infiltration in cancer stroma niches.

ABSTRACT:

Introduction

Sex-determining region Y-related high-mobility group box 17 protein (SOX17), a proangiogenic transcription factor, is specifically expressed in tumor endothelial cells (TECs) of implanted Lewis lung carcinoma. However, the expression profile of SOX17 is largely unknown in human lung cancer. We aimed to elucidate SOX17 expression in cancer cells and the tumor microenvironment of lung adenocarcinoma.

Methods

In the present study, we examined SOX17 expression in whole-tissue specimens of 83 lung adenocarcinomas by immunohistochemistry.

Results

SOX17 immunoreactivity was minimal in lung adenocarcinoma cells, except in five non-mucinous adenocarcinomas in situ. SOX17 was also expressed in cultured A549 lung adenocarcinoma cells, which is widely used as a model

SUBMITTER: Yamamoto H 

PROVIDER: S-EPMC11554551 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature