Bacteriophages, gut bacteria, and microbial pathways interplay in cardiometabolic health.

ABSTRACT: Cardiometabolic diseases are leading causes of mortality in Western countries. Well-established risk factors include host genetics, lifestyle, diet, and the gut microbiome. Moreover, gut bacterial communities and their activities can be altered by bacteriophages (also known simply as phages), bacteria-infecting viruses, making these biological entities key regulators of human cardiometabolic health. The manipulation of bacterial populations by phages enables the possibility of using phages in the treatment of cardiometabolic diseases through phage therapy and fecal viral transplants. First, however, a deeper understanding of the role of the phageome in cardiometabolic diseases is required. In this review, we first introduce the phageome as a component of the gut microbiome and discuss feca

SUBMITTER: Kirk D 

PROVIDER: S-EPMC11554570 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature