Small molecule-mediated targeting of microRNAs for drug discovery: Experiments, computational techniques, and disease implications.

ABSTRACT: Small molecules have been providing medical breakthroughs for human diseases for more than a century. Recently, identifying small molecule inhibitors that target microRNAs (miRNAs) has gained importance, despite the challenges posed by labour-intensive screening experiments and the significant efforts required for medicinal chemistry optimization. Numerous experimentally-verified cases have demonstrated the potential of miRNA-targeted small molecule inhibitors for disease treatment. This new approach is grounded in their posttranscriptional regulation of the expression of disease-associated genes. Reversing dysregulated gene expression using this mechanism may help control dysfunctional pathways. Furthermore, the ongoing improvement of algorithms has allowed for the integration of computat

SUBMITTER: Sun J 

PROVIDER: S-EPMC11554572 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature