Compensatory mechanisms amidst demyelinating disorders: insights into cognitive preservation.

ABSTRACT: Demyelination disrupts the transmission of electrical signals in the brain and affects neurodevelopment in children with disorders such as multiple sclerosis and myelin oligodendrocyte glycoprotein-associated disorders. Although cognitive impairments are prevalent in these conditions, some children maintain cognitive function despite substantial structural injury. These findings raise an important question: in addition to the degenerative process, do compensatory neural mechanisms exist to mitigate the effects of myelin loss? We propose that a multi-dimensional approach integrating multiple neuroimaging modalities, including diffusion tensor imaging, magnetoencephalography and eye-tracking, is key to investigating this question. We examine the structural and functional connectivity of the

SUBMITTER: Al Dahhan NZ 

PROVIDER: S-EPMC11554762 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature