Waist circumference-years and cancer risk: a prospective study of the association and comparison of predictive performance with waist circumference and body mass index.

ABSTRACT:

Background

Associations of waist circumferences (WC) and body mass index (BMI) measured once or over time, with cancer incidence were studied. WC is associated with some cancers independent of BMI. Analyses of cumulative central adiposity and cancer are lacking. We investigated associations between waist circumference-years, incorporating exposure time to WC ≥ 102 cm in men or ≥88 cm in women, and cancer, and compared this with single WC or BMI.

Methods

Serial WC measurements taken over 9 years in the prospective Atherosclerosis Risk in Communities Study (ARIC) predicted yearly WC. Cox proportional hazards regression estimated hazard ratios (HRs) of cancer incidence for waist circumference-years, WC or BMI, measured in Visit 4. Harrell's C-statistic quantified metric predict

SUBMITTER: Hawwash N 

PROVIDER: S-EPMC11554801 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature