Brain amyloid load, subjective memory complaints, and cognitive trajectories in older individuals at risk for dementia.

ABSTRACT:

Background and purpose

This study evaluated associations of brain amyloid with 2-year objective and subjective cognitive measures in a trial-ready older general population at risk for dementia.

Methods

Forty-eight participants in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability underwent ¹¹C-Pittsburgh compound B (PiB) positron emission tomography (PET) scans and assessment of cognition (modified Neuropsychological Test Battery [NTB]) and subjective memory complaints (Prospective and Retrospective Memory Questionnaire).

Results

Mean age was 71.4 ± 5.06 years, and 20 participants (42%) had positive baseline PiB-PET scans. Amyloid positivity was associated with lower NTB executive function at baseline and less favorable

SUBMITTER: Saadmaan G 

PROVIDER: S-EPMC11554848 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature