Cholinergic dysfunction in isolated rapid eye movement sleep behaviour disorder links to impending phenoconversion.

ABSTRACT:

Background and purpose

Most patients with isolated rapid eye movement sleep behaviour disorder (iRBD) progress to a parkinsonian alpha-synucleinopathy. However, time to phenoconversion shows great variation. The aim of this study was to investigate whether cholinergic and dopaminergic dysfunction in iRBD patients was associated with impending phenoconversion.

Methods

Twenty-one polysomnography-confirmed iRBD patients underwent baseline ¹¹C-donepezil and 6-Fluoro-(¹⁸F)-l-3,4-dihydroxyphenylalanine (¹⁸F-DOPA) positron emission tomography (PET). Potential phenoconversion was monitored for up to 8 years. PET images were analysed according to patients' diagnoses after 3 and 8 years using linear regression. Time-to-event analysis was made with Cox

SUBMITTER: Terkelsen MH 

PROVIDER: S-EPMC11554850 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature