Elevated serum circulating cell-free mitochondrial DNA in amyotrophic lateral sclerosis.

ABSTRACT:

Background and purpose

The substantial role of inflammation in amyotrophic lateral sclerosis (ALS) is gaining support from recent research. Studies indicate that circulating cell-free mitochondrial DNA (ccf-mtDNA) can activate the immune system and is associated with neurodegenerative diseases. This research was designed to quantify ccf-mtDNA levels in the serum of ALS patients.

Methods

The medical records of ALS patients were reviewed. Serum ccf-mtDNA levels of patients with ALS (n = 62) and age-matched healthy controls (n = 46) were measured and compared. Additionally, serum interleukin-6 (IL-6) levels were measured using an enzyme-linked immunosorbent assay in 26 ALS patients. Correlations between variables were analyzed.

Results

Serum ccf-mtDNA was notably higher

SUBMITTER: Li J 

PROVIDER: S-EPMC11554856 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature