Heart rate variability biofeedback for critical illness polyneuropathy: a randomized sham-controlled study.

ABSTRACT:

Background and purpose

Critical illness polyneuropathy (CIP) has been linked to neurocardiac dysfunction mediated by autonomic nervous system dysregulation, which increases mortality. We aimed to assess if heart rate variability (HRV) biofeedback could improve neurocardiac function in CIP.

Methods

We randomly allocated (1:1) patients with electrophysiologically confirmed CIP undergoing early inpatient neurological rehabilitation to additional HRV or sham biofeedback over 14 days. We evaluated neurocardiac function via standard deviation of normal-to-normal intervals (SDNN) as the primary outcome, as well as HRV frequency domains, sympathetic cutaneous sudomotor and vasomotor functions and disability at baseline, post intervention and 4 weeks later. The study is registered on

SUBMITTER: Sedghi A 

PROVIDER: S-EPMC11554868 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature