Progesterone receptor is constitutively expressed in induced Pluripotent Stem Cells (iPSCs).

ABSTRACT: Induced Pluripotent Stem Cells (iPSCs) are nowadays a common starting point for wide-ranging applications including 3D disease modeling (i.e. organoids) and in future regenerative medicine. Physiological processes like homeostasis, cell differentiation, development and reproduction are tightly regulated by hormones through binding to their transmembrane or nuclear receptors of target cells. Considering their pleiotropic effect, take into account also their expression in an iPSCs-based disease modeling would better recapitulate the molecular events leading to 3D organoid development and disease study. Here we reported the expression pattern of estrogen receptor (ERα) and progesterone receptor (PR) in four different iPSCs, obtained from CD34 + progenitor cells and skin fibroblasts with four

SUBMITTER: Manganelli M 

PROVIDER: S-EPMC11554879 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature