Population Pharmacokinetics of Loxoprofen and its alcoholic metabolites in healthy Korean men.

ABSTRACT:

Background

Loxoprofen has been actively used clinically to relieve musculoskeletal pain and inflammatory symptoms. However, there are few reports on quantitative pharmacokinetic (PK) prediction tools and diversity analyzes for loxoprofen within populations.

Objectives

The aim of this study was to identify effective covariates associated with explaining inter-individual PK variability through a population pharmacokinetic (Pop-PK) modeling approach for loxoprofen, and to provide a starting point for establishing scientific dosing regimens.

Method

The bioequivalence PK results of loxoprofen performed on 52 healthy Korean men and the physiological and biochemical parameters derived from each individual were used as base data for the development of a Pop-PK model of loxopr

SUBMITTER: Jang JH 

PROVIDER: S-EPMC11554985 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature