Glymphatic system dysfunction and risk of clinical milestones in patients with Parkinson disease.

ABSTRACT:

Background and purpose

Glymphatic dysfunction may play a significant role in the development of neurodegenerative diseases. We aimed to evaluate the association between glymphatic dysfunction and the risk of malignant event/clinical milestones in Parkinson disease (PD).

Methods

This study included 236 patients from August 2014 to December 2020. Diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) index was calculated as an approximate measure of glymphatic function. The primary outcomes were four clinical milestones including recurrent falls, wheelchair dependence, dementia, and placement in residential or nursing home care. The associations of DTI-ALPS with the risk of clinical milestones were examined using multivariate Cox proportional hazards regress

SUBMITTER: Zhou C 

PROVIDER: S-EPMC11554988 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature