Endothelium-related biomarkers and cognitive decline in prevalent hemodialysis patients: A prospective cohort study.

ABSTRACT:

Introduction

Cognitive decline is prevalent in maintenance hemodialysis patients. The blood-brain barrier has been implicated in cognitive decline. In this prospective cohort study, we investigated the associations between endothelium-related biomarkers and steeper cognitive decline in this population.

Methods

Cognitive function was assessed using the Portuguese-adapted Cambridge Cognitive Examination (CAMCOG) with items of the Mini-Mental State Examination (MMSE). Endothelium-related biomarkers included syndecan-1, ICAM-1, VCAM-1 and angiopoietin-2 (AGPT2). Patients were followed up for 4 years, and cognitive assessments were repeated. Multinomial regression analyses were performed to evaluate associations between biomarkers and cognitive decline.

Results

A total of

SUBMITTER: Liborio AB 

PROVIDER: S-EPMC11555003 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature