Serum liver enzymes and risk of stroke: Systematic review with meta-analyses and Mendelian randomization studies.

ABSTRACT:

Background and purpose

Previous observational studies have identified correlations between liver enzyme levels and stroke risk. However, the strength and consistency of these associations vary. To comprehensively evaluate the relationship between liver enzymes and stroke risk, we conducted meta-analyses complemented by Mendelian randomization (MR) analyses.

Methods

Following the PRISMA guidelines, we performed meta-analyses of prospective studies and conducted subgroup analyses stratified by sex and stroke subtype. Subsequently, adhering to the STROBE-MR guidelines, we performed two-sample bidirectional univariable MR (UVMR) and multivariable MR (MVMR) analyses using the largest genome-wide association studies summary data. Finally, the single-nucleotide polymorphisms associ

SUBMITTER: Li C 

PROVIDER: S-EPMC11555028 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature