Targeting resistant breast cancer stem cells in a three-dimensional culture model with oleuropein encapsulated in methacrylated alginate microparticles.

ABSTRACT:

Background

Cancer stem cells (CSCs) are a subpopulation of cancer cells that are believed to be responsible for tumor initiation, progression, metastasis, and resistance to conventional therapies. Oleuropein as a natural compound found in olive leaves and olive oil, has potential therapeutic effects in cancer treatment, particularly in targeting CSCs. It induces apoptosis in CSCs while sparing normal cells, inhibit proliferation, migration, and invasion, and suppress the self-renewal ability of CSCs. Additionally, oleuropein has shown synergistic effects with conventional chemotherapy drugs, enhancing their efficacy against CSCs.

Objectives

This study aims to selectively target therapeutically resistant cancer stem cells (CSCs) within a heterogeneous tumor population by util

SUBMITTER: Altundag-Erdogan O 

PROVIDER: S-EPMC11555036 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature