Partial volume correction for Lu-177-PSMA SPECT.

ABSTRACT:

Background

The limited spatial resolution in SPECT images leads to partial volume effect (PVE), degrading the subsequent dosimetric accuracy. We aim to quantitatively evaluate PVE and partial volume corrections (PVC), i.e., recovery coefficient (RC)-PVC (RC-PVC), reblurred Van-Cittert (RVC) and iterative Yang (IY), in ¹⁷⁷Lu-PSMA-617 SPECT images.

Methods

We employed a geometrical cylindrical phantom containing five spheres (diameters ranging from 20 to 40 mm) and 40 XCAT phantoms with various anatomical variations and activity distributions. SIMIND Monte Carlo code was used to generate realistic noisy projections. In the clinical study, sequential quantitative SPECT/CT imaging at 4 time-points post ¹⁷⁷Lu-PSMA-617 injections were analyzed for 10 patients

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11555037 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature