Circadian desynchrony in early life leads to enduring autistic-like behavioral changes in adulthood.

ABSTRACT: Circadian rhythm regulates a variety of biological processes in almost all living organisms. Modern lifestyles, e.g. transmeridian travel, night shift, light at night, etc., frequently disrupt people's regular sleep-wake cycles and create a misalignment (circadian desynchrony) between the natural environment and the endogenous body clock, and between different circadian oscillators within the body. The long-term consequences of circadian desynchrony on neurodevelopment and adult behavior remain elusive. Increasing clinical evidence supports a correlation between the disruption of the circadian system and neurodevelopmental disorders, such as autism spectrum disorders. Despite clinical correlations, experimental evidence is yet to establish a link between circadian disturbance in early life

SUBMITTER: Mishra A 

PROVIDER: S-EPMC11555041 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature