Formulation and characterization of nanofibrous scaffolds incorporating extracellular vesicles loaded with curcumin.

ABSTRACT: Due to their small size, flexibility, and adhesive properties, extracellular vesicles (EVs) hold promises as effective drug delivery systems. However, challenges such as the variability in vesicle types and the need to maintain their integrity for medical applications exist. Curcumin, a compound found in turmeric and known for its diverse health benefits, including anti-cancer and anti-inflammatory properties, faces obstacles in clinical use due to issues like low solubility, limited absorption, and rapid breakdown in the body. This study aimed to incorporate large-sized curcumin-loaded extracellular vesicles (lEVs) into fast-dissolving nanofibers made of poly(vinyl alcohol) (PVA) by electrospinning. By using aqueous PVA-based solutions for electrospinning, the presence of curcumin-loaded

SUBMITTER: Kazsoki A 

PROVIDER: S-EPMC11555084 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature