Clinical and laboratory characteristics during a 1-year follow-up in European Lyme neuroborreliosis: A prospective cohort study.

ABSTRACT:

Background and purpose

We need more knowledge on clinical presentations, time course, biomarkers, and prognosis in European Lyme neuroborreliosis (LNB).

Methods

A prospective 12-month follow-up of predetermined clinical and laboratory parameters was undertaken in 105 patients with LNB.

Results

At presentation, 79% had radiculopathy, 49% had facial palsy, and 13% had solely subjective symptoms (predominately pain). Intrathecally produced Borrelia burgdorferi (Bb) antibodies were demonstrated and cerebrospinal fluid (CSF) CXCL13 was positive in 85% and 82% pretreatment, in 73% and 10% at 6 months, and in 58% and 14% at 12 months, respectively. CSF Bb polymerase chain reaction (PCR) was positive in 40% pretreatment. In four patients who tested negative for Bb antibodies

SUBMITTER: Solheim AM 

PROVIDER: S-EPMC11555137 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature