Difference in trajectories according to early amyloid accumulation in cognitively unimpaired elderly.

ABSTRACT:

Background and purpose

Amyloid β (Aβ), a major biomarker of Alzheimer's disease, leads to tau accumulation, neurodegeneration and cognitive decline. Modelling the trajectory of Aβ accumulation in cognitively unimpaired (CU) individuals is crucial, as treatments targeting Aβ are anticipated. The evolution of Aβ levels was investigated to determine whether it could lead to classification into different groups by studying longitudinal Aβ changes in older CU individuals, and differences between the groups were compared.

Methods

A total of 297 CU participants were included from the Alzheimer's Disease Neuroimaging Initiative database, and these participants underwent apolipoprotein E (APOE) genotyping, neuropsychological testing, brain magnetic resonance imaging, and an average o

SUBMITTER: Kim YJ 

PROVIDER: S-EPMC11555158 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature