Randomized, Blinded, Controlled Clinical Trial of Polylactide-Collagen Scaffold in Treatment of Shoulder Osteochondritis Dissecans in Dogs.

ABSTRACT:

Objective

 The aim of our study was to investigate a degradable polylactide-collagen scaffold (COPLA) in the treatment of shoulder osteochondritis dissecans (OCD) in dogs.

Study design

 The study was a controlled, randomized, blinded clinical trial with a parallel group design with a 1.5-year follow-up. Twenty dogs with uni- or bilateral shoulder OCD (29 shoulders) were randomized to receive a COPLA or arthroscopic debridement only (Control). The outcome of treatment was assessed with gait and stance analysis, passive range of motion measurement, pain and lameness evaluation, Helsinki Chronic Pain Index, and computed tomography (CT).

Results

 Eighteen dogs (25 shoulders) completed the study. The clinical outcome variables improved significantly from baseline in COPLA

SUBMITTER: Heikkila H 

PROVIDER: S-EPMC11555192 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature