Resveratrol protects pancreatic beta cell and hippocampal cells from the aggregate-prone capacity of hIAPP.

ABSTRACT: Type 2 diabetes mellitus and Alzheimer's disease, are two closely related pathological situations that are connected at the molecular level. In recent years, amylin, which is co-secreted with insulin, has been proposed for being a main actor in this context due to its capacity to form aggregates in a β-sheet-like structure. In a diabetic milieu, there is an increase in the production and secretion of insulin and amylin. We have analysed the role of resveratrol on aggregate formation and in the production of extracellular vesicles with amylin in its interior and in pancreatic β cells overexpressing human amylin (INS1E-hIAPP). Furthermore, we have explored the consequences of the exposition of the conditioned medium derived from INS1E-hIAPP in the hippocampal cell line HT-22 and the role of

SUBMITTER: Gonzalez-Blanco C 

PROVIDER: S-EPMC11555266 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature