Causal relationship between sarcopenia and rotator cuff tears: a Mendelian randomization study.

ABSTRACT:

Background

Sarcopenia and rotator cuff tears are common among elderly patients. However, the role of sarcopenia in the management of rotator cuff tears has been often overlooked. This study aimed to elucidate the effects of sarcopenia-related traits on rotator cuff tears.

Methods

Two-sample Mendelian randomization (MR) analyses based on genome-wide association study data were used to evaluate the causal relationships among appendicular lean mass (ALM), usual walking pace, low hand grip strength, and rotator cuff tears. Multivariate Mendelian randomization (MVMR) analyses were used to evaluate the direct effects of each muscle trait on the causal relationship.

Results

Univariate MR analysis showed that ALM and usual walking pace were causally related to rotator cuff te

SUBMITTER: Yang D 

PROVIDER: S-EPMC11555288 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature