Progranulin enhances the engraftment of transplanted human iPS cell-derived cerebral neurons.

ABSTRACT: Cerebral organoids (COs) in cell replacement therapy offer a viable approach to reconstructing neural circuits for individuals suffering from stroke or traumatic brain injuries. Successful transplantation relies on effective engraftment and neurite extension from the grafts. Earlier research has validated the effectiveness of delaying the transplantation procedure by 1 week. Here, we hypothesized that brain tissues 1 week following a traumatic brain injury possess a more favorable environment for cell transplantation when compared to immediately after injury. We performed a transcriptomic comparison to differentiate gene expression between these 2 temporal states. In controlled in vitro conditions, recombinant human progranulin (rhPGRN) bolstered the survival rate of dissociated neurons so

SUBMITTER: Yamagami K 

PROVIDER: S-EPMC11555480 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature