Synergistic Effect of Cytochrome P450 Family 3 Subfamily A Member 5 (<i>CYP3A5)</i> Genetic Variants in Tacrolimus Dose Determination in Indian Renal Transplant Patients.

ABSTRACT: Tacrolimus (TAC) has a narrow therapeutic index and shows interindividual variabilities in its blood concentration. Although guidelines recommend a genetic variant (rs776746) to determine the optimized TAC dose, discrepancies in accuracy have been noted. Therefore, studying other variants of CYP3A5 may improve the accuracy of the TAC dose. Clinical exome sequencing (CES) was performed in 219 renal transplant patients. The SNPs of CYP3A5 covered by CES were recorded. The TAC blood trough concentration/dose (C ₀/D) was calculated on day 7 and months 1, 3, 6, and 12 of post-transplantation, and association with CYP3A5 genotypes was studied. Further, biopsy-proven rejection and pathological events were analyzed for their association with CYP3A5<

SUBMITTER: Hemani RJ 

PROVIDER: S-EPMC11555502 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature