Brain Networks for Cortical Atrophy and Responsive Neurostimulation in Temporal Lobe Epilepsy.

ABSTRACT:

Importance

Drug-resistant temporal lobe epilepsy (TLE) has been associated with hippocampal pathology. Most surgical treatment strategies, including resection and responsive neurostimulation (RNS), focus on this disease epicenter; however, imaging alterations distant from the hippocampus, as well as emerging data from responsive neurostimulation trials, suggest conceptualizing TLE as a network disorder.

Objective

To assess whether brain networks connected to areas of atrophy in the hippocampus align with the topography of distant neuroimaging alterations and RNS response.

Design, setting, and participants

This retrospective case-control study was conducted between July 2009 and June 2022. Data collection for this multicenter, population-based study took place across 4

SUBMITTER: Lariviere S 

PROVIDER: S-EPMC11555549 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature