Targeted antimicrobial self-assembly peptide hydrogel with in situ bio-mimic remineralization for caries management.

ABSTRACT: The single-function agents with wide-spectrum activity which tend to disturb the ecological balance of oral cavity cannot satisfy dental treatment need. A multi-functional agent with specifically targeted killing property and in situ remineralization is warranted for caries management. A novel multi-functional agent (8DSS-C8-P-113) consisting of three domains, i.e., a non-specific antimicrobial peptide (AMP) (P-113), a competence stimulating peptide (C8), and an enhancing remineralization domain (8DSS), is fabricated and evaluated in this study. The findings demonstrates that 2 μM mL^-1 of 8DSS-C8-P-113 eliminates planktonic Streptococcus mutans (S. mutans) without disrupting the oral normal flora. At a concentration of 8 μM mL^-1, it exhibits the ability

SUBMITTER: Zhou L 

PROVIDER: S-EPMC11555604 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature