Differences in 21-Gene and PAM50 Recurrence Scores in Younger and Black Women With Breast Cancer.

ABSTRACT:

Purpose

Genomic tests, such as the Oncotype Dx 21-gene and Prosigna risk of recurrence (ROR-P) assay, are commonly used for breast cancer prognostication. Emerging data suggest variability between assays, but this has not been compared in diverse populations.

Materials and methods

RNA sequencing was performed on 647 previously untreated stage I-III estrogen receptor-positive/human epidermal growth factor receptor 2-negative tumors in the Carolina Breast Cancer Study, which oversampled Black and younger women (age <50 years at diagnosis), using research versions of two common RNA-based prognostic assays: ROR-P_R and the 21-gene recurrence score (RS_R). Relative frequency differences and 95% CIs were estimated for associations with race and age, and hazards

SUBMITTER: Van Alsten SC 

PROVIDER: S-EPMC11555617 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature