Highly Effective Biocides against <i>Pseudomonas aeruginosa</i> Reveal New Mechanistic Insights Across Gram-Negative Bacteria.

ABSTRACT: Pseudomonas aeruginosa is a major nosocomial pathogen that persists in healthcare settings despite rigorous disinfection protocols due to intrinsic mechanisms conferring resistance. We sought to systematically assess cationic biocide efficacy against this pathogen using a panel of multidrug-resistant P. aeruginosa clinical isolates. Our studies revealed widespread resistance to commercial cationic disinfectants that are the current standard of care, raising concerns about their efficacy. To address this shortcoming, we highlight a new class of quaternary phosphonium compounds that are highly effective against all members of the panel. To understand the difference in efficacy, mechanism of action studies were carried out, which identified a discrete inner-membrane selective ta

SUBMITTER: Sanchez CA 

PROVIDER: S-EPMC11555683 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature