Intestinal tuft cell immune privilege enables norovirus persistence.

ABSTRACT: The persistent murine norovirus strain MNV^CR6 is a model for human norovirus and enteric viral persistence. MNV^CR6 causes chronic infection by directly infecting intestinal tuft cells, rare chemosensory epithelial cells. Although MNV^CR6 induces functional MNV-specific CD8⁺ T cells, these lymphocytes fail to clear infection. To examine how tuft cells promote immune escape, we interrogated tuft cell interactions with CD8⁺ T cells by adoptively transferring JEDI (just EGFP death inducing) CD8⁺ T cells into Gfi1b-GFP tuft cell reporter mice. Unexpectedly, some intestinal tuft cells partially resisted JEDI CD8⁺ T cell-mediated killing-unlike Lgr5⁺ intestinal stem cells and extraintestinal tuft cells-despite

SUBMITTER: Strine MS 

PROVIDER: S-EPMC11555782 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature