Association of plasma homocysteine with cardiometabolic multimorbidity: a cross-sectional study in northwest China.

ABSTRACT:

Background

Elevated homocysteine (Hcy) levels have been linked to cardiovascular disease (CVD), but their association with cardiometabolic multimorbidity (CMM) remains uncertain.

Methods

Data from the baseline survey of the China Northwest Cohort-Ningxia Project (CNC-NX) were used to recruit 22,566 participants. Demographic characteristics, lifestyle factors, and laboratory exam results were collected. Logistic regression was used to evaluate the association between Hcy levels and CMM risk. Restricted cubic splines (RCS) explored potential non-linear relationships, and subgroup analyses assessed the consistency of the association across distinct groups. Sensitivity analysis accounted for cluster variability.

Results

The final analysis included 18,126 participants. Hig

SUBMITTER: Qiu J 

PROVIDER: S-EPMC11555799 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature