Cytokine and growth factor correlation networks associated with morbidities in extremely preterm infants.

ABSTRACT:

Background

Cytokines and growth factors (GF) have been implicated in the development of retinopathy of prematurity (ROP) and bronchopulmonary dysplasia (BPD). We hypothesize that even small coordinated changes in inflammatory proteins or GFs may reveal changes in underlying regulating mechanisms that do not induce obvious changes in concentration of individual proteins. We therefore applied correlation network analysis of serum factors to determine early characteristics of these conditions.

Methods

Concentrations of 17 cytokines and five GFs were measured and analysed in blood samples from cord blood, on day one and during the following month in 72 extremely preterm infants. Spearman's correlation networks distinguishing BPD and severe ROP patients from non-affected were cre

SUBMITTER: Golubinskaya V 

PROVIDER: S-EPMC11555815 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature