An integrated microbiome- and metabolome-genome-wide association study reveals the role of heritable ruminal microbial carbohydrate metabolism in lactation performance in Holstein dairy cows.

ABSTRACT:

Background

Despite the growing number of studies investigating the connection between host genetics and the rumen microbiota, there remains a dearth of systematic research exploring the composition, function, and metabolic traits of highly heritable rumen microbiota influenced by host genetics. Furthermore, the impact of these highly heritable subsets on lactation performance in cows remains unknown. To address this gap, we collected and analyzed whole-genome resequencing data, rumen metagenomes, rumen metabolomes and short-chain fatty acids (SCFAs) content, and lactation performance phenotypes from a cohort of 304 dairy cows.

Results

The results indicated that the proportions of highly heritable subsets (h² ≥ 0.2) of the rumen microbial composition (55%), functio

SUBMITTER: Zhang C 

PROVIDER: S-EPMC11555892 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature