The impact of androgen-induced translation in modulating androgen receptor activity.

ABSTRACT:

Introduction

Dysregulated androgen receptor (AR) activity is central to various diseases, particularly prostate cancer (PCa), in which it drives tumour initiation and progression. Consequently, antagonising AR activity via anti-androgens is an indispensable treatment option for metastatic PCa. However, despite initial tumour remission, drug resistance occurs. Therefore, the AR signalling pathway has been intensively investigated. However, the role of AR protein stability in AR signalling and therapy resistance has not yet been deciphered. Therefore, this study aimed to investigate the role of AR protein changes in transactivity and assess its mechanism as a possible target in PCa.

Methods

LNCaP, C4-2, and 22Rv1 cells were treated with R1881, enzalutamide, cycloheximide, and

SUBMITTER: Israel JS 

PROVIDER: S-EPMC11555926 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature