Enhanced vitamin B₁₂ production by isolated Bacillus strains with the application of response surface methodology.

ABSTRACT:

Background

Vitamin B₁₂ is a crucial B-group vitamin, first isolated from the liver due to its role in combating pernicious anemia. It is distinguished by its unique and complex structure, which makes its chemical synthesis challenging and expensive. Consequently, vitamin B₁₂ is alternatively obtained through microbial fermentations. Molasses, an affordable and safe agro-industrial waste, can be used as a carbon source for vitamin B₁₂ production, offering a cost-effective alternative to expensive sugars in the production medium.

Results

A total of 87 yeast, actinomycete, and bacterial isolates were screened for vitamin B₁₂ production, with 15 isolates showing high productivity. Bacillus isolates were selected for further analysis us

SUBMITTER: Abdel-Baki RMM 

PROVIDER: S-EPMC11555979 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature