Distinct neutrophil effector functions in response to different isolates of Leishmania aethiopica.

ABSTRACT:

Background

In Ethiopia, cutaneous leishmaniasis is mainly caused by Leishmania (L.) aethiopica parasites and presents in three main clinical forms. It is still not clear if the host immune response plays a role in the development of these different presentations. Since neutrophils are likely to be one of the first immune cells present at the site of the sand fly bite, we set up an in vitro model of infection of neutrophils with L. aethiopica and assessed some of the main neutrophil effector functions: association with and internalisation of parasites, apoptosis and ROS production. We used three freshly isolated clinical isolates and one isolate that has been kept in culture for decades.

Results

Our results showed by flow cytometry that all four L. aethiopica isolates had the

SUBMITTER: Adem E 

PROVIDER: S-EPMC11555981 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature