Investigation of GPM6B as a novel therapeutic target in Osteoarthritis.

ABSTRACT:

Background

Osteoarthritis (OA) is the most common motor system disease in older people, characterized by a high incidence and significant social and economic burden. Women have a higher risk of OA, more severe clinical symptoms, and a higher rate of disabilities than men. However, the pathogenesis of OA remains unclear. Therefore, we screened for differentially expressed genes (DEGs) in OA patients of different sex and searched for new targets that may be involved in regulating the development of OA.

Methods

The study compared the expression of DEGs in synovial fluid exosomes between male and female patients with OA through RNA sequencing combined with bioinformatics analysis using public data. To evaluate the screened DEGs, synovial tissue and fluid samples were obtained fr

SUBMITTER: Feng C 

PROVIDER: S-EPMC11556152 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature