DNA methylation analysis is used to identify novel genetic loci associated with circulating fibrinogen levels in blood.

ABSTRACT:

Background

Fibrinogen plays an essential role in blood coagulation and inflammation. Circulating fibrinogen levels may be determined based on interindividual differences in DNA methylation at cytosine-phosphate-guanine (CpG) sites and vice versa.

Objectives

To perform an EWAS to examine an association between blood DNA methylation levels and circulating fibrinogen levels to better understand its biological and pathophysiological actions.

Methods

We performed an epigenome-wide association study of circulating fibrinogen levels in 18 037 White, Black, American Indian, and Hispanic participants, representing 14 studies from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium. Circulating leukocyte DNA methylation was measured using the Illumina 45

SUBMITTER: Hahn J 

PROVIDER: S-EPMC11556295 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature