Detectability of runs of homozygosity is influenced by analysis parameters and population-specific demographic history.

ABSTRACT: Wild populations are increasingly threatened by human-mediated climate change and land use changes. As populations decline, the probability of inbreeding increases, along with the potential for negative effects on individual fitness. Detecting and characterizing runs of homozygosity (ROHs) is a popular strategy for assessing the extent of individual inbreeding present in a population and can also shed light on the genetic mechanisms contributing to inbreeding depression. Here, we analyze simulated and empirical datasets to demonstrate the downstream effects of program selection and long-term demographic history on ROH inference, leading to context-dependent biases in the results. Through a sensitivity analysis we evaluate how various parameter values impact ROH-calling results, highlightin

SUBMITTER: Silva GAA 

PROVIDER: S-EPMC11556709 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature