Structural influences on synaptic plasticity: The role of presynaptic connectivity in the emergence of E/I co-tuning.

ABSTRACT: Cortical neurons are versatile and efficient coding units that develop strong preferences for specific stimulus characteristics. The sharpness of tuning and coding efficiency is hypothesized to be controlled by delicately balanced excitation and inhibition. These observations suggest a need for detailed co-tuning of excitatory and inhibitory populations. Theoretical studies have demonstrated that a combination of plasticity rules can lead to the emergence of excitation/inhibition (E/I) co-tuning in neurons driven by independent, low-noise signals. However, cortical signals are typically noisy and originate from highly recurrent networks, generating correlations in the inputs. This raises questions about the ability of plasticity mechanisms to self-organize co-tuned connectivity in neurons

SUBMITTER: Giannakakis E 

PROVIDER: S-EPMC11556753 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature