Eye Adult Changes in Thought (Eye ACT) Study: Design and Report on the Inaugural Cohort.

ABSTRACT:

Background

Conflicting research on retinal biomarkers of Alzheimer's disease and related dementias (AD/ADRD) is likely related to limited sample sizes, study design, and protocol differences.

Objective

The prospective Eye Adult Changes in Thought (Eye ACT) seeks to address these gaps.

Methods

Eye ACT participants are recruited from ACT, an ongoing cohort of dementia-free, older adults followed biennially until AD/ADRD, and undergo visual function and retinal imaging assessment either in clinic or at home.

Results

330 participants were recruited as of 03/2023. Compared to ACT participants not in Eye ACT (N = 1868), Eye ACT participants (N = 330) are younger (mean age: 70.3 versus 71.2, p = 0.014), newer to ACT (median ACT visits since baseline: 3 versus 4, p < 0

SUBMITTER: Lee CS 

PROVIDER: S-EPMC11556780 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature