Relationship between systolic blood pressure and renal function on clinical outcomes in patients with atrial fibrillation: a report from the prospective AF-GEN-UK Registry.

ABSTRACT:

Background

Blood pressure (BP) extremes and renal (dys)function contribute to poor outcomes in patients with atrial fibrillation (AF). Using data from the prospective AF-GEN-UK study, we investigated the effect of systolic BP and interaction with renal function for prognostication.

Methods

Baseline systolic BP (SBP) values were recorded for 1580 patients (mean [SD] age 71 [11] years, 60% male) and categorized as follows: 120-129 mmHg ( n  = 289, reference group) <110 mmHg ( n  = 165), 110-119 mmHg, ( n  = 254), 130-139 mmHg ( n  = 321), 140-159 mmHg ( n  = 385) and ≥160 mmHg ( n  = 166). Cox regression analysis, adjusted for age, oral anticoagulation (OAC) and CHA 2 DS 2 -VASc score established the impact of SBP, renal function and their interaction on 1-year outcomes. SBP g

SUBMITTER: Shantsila A 

PROVIDER: S-EPMC11556885 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature