Multi-domain predictors of grip strength differentiate individuals with and without alcohol use disorder.

ABSTRACT: Grip strength is considered one of the simplest and reliable indices of general health. Although motor ability and strength are commonly affected in people with alcohol use disorder (AUD), factors predictive of grip strength decline in AUD have not been investigated. Here, we employed a data-driven analysis predicting grip strength from measurements in 53 controls and 110 AUD participants, 53 of whom were comorbid with HIV infection. Controls and AUD were matched on sex, age, and body mass index. Measurements included commonly available metrics of brain structure, neuropsychological functioning, behavioural status, haematological and health status, and demographics. Based on 5-fold stratified cross-validation, a machine learning approach predicted grip strength separately for each cohort.

SUBMITTER: Paschali M 

PROVIDER: S-EPMC11556900 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature