Association between gut microbiota, plasma metabolites, and ovarian cancer: A Mendelian randomization study.

ABSTRACT: Numerous studies have demonstrated a correlation between alterations in gut microbiota (GM) and levels of body metabolites in ovarian cancer (OC). However, the specific causal relationships underlying these associations remain unclear. This study utilized summary statistics of GM from the MiBioGen consortium, along with an unprecedented dataset comprising 1091 blood metabolites and 309 metabolite ratios from the UK Biobank, in conjunction with OC data from the FinnGen Consortium R9 release. We conducted bidirectional Mendelian randomization (MR) analyses to investigate the causal relationships between GM and OC. Additionally, a two-step MR approach was employed to identify potential mediating metabolites. Our analysis revealed significant associations between 6 specific microbiota taxa and

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11556969 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature