Exploring causal associations between dietary intake and liver diseases: A bidirectional Mendelian randomization study.

ABSTRACT: Previous evidence suggests that dietary intake can affect liver diseases; However, the causal relationship between dietary intake and liver diseases remains unclear. To investigate this, we conducted a bidirectional Mendelian randomization (MR) analysis to comprehensively assess the potential causal relationship between dietary intake and liver diseases. Two-sample bidirectional MR was performed based on genome-wide association studies summary data from the UK Biobank and FinnGen database. The primary analysis method for evaluating causal relationships was inverse-variance weighted. Supplementary analyses included MR-Egger and weighted median methods. Subsequently, sensitivity analyses were performed using Cochran Q test, MR-Egger intercept test, MR-PRESSO, RadialMR, and leave-one-out anal

SUBMITTER: Wang H 

PROVIDER: S-EPMC11557105 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature