CCN3/NOV as a potential therapeutic target for diverticular disease: A proteome-wide Mendelian randomization study.

ABSTRACT: Genome-wide association studies (GWAS) identified over 100 susceptibility loci and candidate causal genes for diverticular disease (DD) at the transcriptional level. However, effective therapeutics or preventions based on underlying disease mechanisms remain to be elucidated. In this study, we explored potential causal genes for DD at the protein level. We used 2 GWAS summary statistics of DD; 1 was obtained from the United Kingdom Biobank (UKBB) with 31,917 cases and 419,135 controls, and the other from the FinnGen consortium with 30,649 cases and 301,931 controls. For the primary analysis, we employed proteome-wide Mendelian randomization (MR) studies using 738 cis-acting protein quantitative trait loci (pQTLs) for 735 plasma proteins from the 5 published studies. For external validation

SUBMITTER: Yoshikawa M 

PROVIDER: S-EPMC11557123 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature